Dichloromethylene diphosphonate

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WebAbstract Dichloromethylene diphosphonate (Cl2MDP), an inhibitor of osteoclast activity, was evaluated for its ability to decrease the excessive mobilization of skeletal calcium … WebDMDP is ingested by phagocytic cells when entrapped in liposomes. Once phagocytized the liposomal membranes are digested and the drug is released into the cell and is ready for action. In vitro, even low doses of liposome-entrapped DMDP caused an significant reduction in cell numbers.

The effect of dichloromethylene diphosphonate, a pyrophosphate analog ...

WebExplore the latest full-text research PDFs, articles, conference papers, preprints and more on EAE. Find methods information, sources, references or conduct a literature review on EAE WebKnow about technical details of Diphosphonate, Dichloromethylene like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at … dating websites for over 50 women

Diphosphonate, Dichloromethylene Drug Information, Uses, …

WebJul 21, 1994 · Dichloromethylene diphosphonate (Cl2MDP), encapsulated into liposomes, is known to eliminate splenic and hepatic macrophages. In the present study we investigated the time course of the effects of i.v. injected Cl2MDP-liposomes on macrophage function in rats from 2 h to 14 days postinjection. WebJun 22, 2005 · Background: Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate-liposomes in order to study the role of these effector cells in the early … WebSigma-Aldrich. 233183. Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem. A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. bj\u0027s wholesale club holidays 2022

Disodium (dichloromethylene)diphosphonate

Dichloromethylene diphosphonate (Cl2MDP) reduces …

WebDichloromethylene diphosphonate (clodronate), a new compound, has powerful activity against osteoclasts and has been used successfully to treat hypercalcemia associated with cancer. We studied... WebSep 1, 1996 · Dichloromethylene diphosphonate (MDPCl 2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to … dating websites for overweight womenWebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone … dating websites for people with hiv

"WebMacrophages in liver and spleen were depleted by administering liposome encapsulated dichloromethylene diphosphonate (clodronate) intravenously 36 h before the instillation of Pseudomonas aeruginosa into the lungs of anesthetized rabbits. Blood samples were analyzed for bacteria and cytokine concentrations. Lung injury was assessed by the ... " - Dichloromethylene diphosphonate

Dichloromethylene diphosphonate

Elimination of phagocytic cells in the spleen after intravenous ...

WebRats received a single intravenous injection with liposome-encapsulated dichloromethylene diphosphonate (C12MDP). This treatment resulted in the … WebMar 15, 2000 · Liposomes containing dichloromethylene diphosphonate (L-DMDP) were injected 45 hours prior to the injection of OxRBC. (A) Liver uptake (circles) and blood decay (triangles) of OxRBC after pretreatment with L-DMDP (closed symbols) or after injection of phosphate-buffered saline (PBS) (open symbols) as control. ...

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WebDes jeunes rats mâles (70–90g) ont été traités pendant dix jours avec 1) l’un des trois diphosphonates suivants: l’éthane-1-hydroxy-1,1-diphosphonate disodique (EHDP), le dichlorométhylène diphosphonate disodique (Cl 2 MDP) ou le méthane-1-cyclohéxyl-1-hydroxy-1,1-diphosphonate disodique (MCHDP), 2) de la calcitonine porcine. WebJul 30, 2012 · A single intra-articular injection of liposomes encapsulating the drug dichloromethylene diphosphonate (CL 2 MDP) in the mouse knee joint caused selective elimination of synovial lining cells. Depletion of cells occurred within a few days as evidenced by light microscopic, electron microscopic and immunohistochemical studies.

Web오늘 하루 그만보기 . p-issn 2287-8696; e-issn 2288-744x; kci; 홈으로 WebMacrophages lining the subcapsular sinus (SCS) and those located in the medulla of popliteal lymph nodes (PLN) of mice were eliminated after subcutaneous (s.c.) injection of dichloromethylene diphosphonate (Cl2MDP)-containing liposomes. No effect of liposome-entrapped Cl2MDP could be seen on nonphag …

WebJul 27, 2013 · INTRODUCTION. Dichloromethylene diphosphonate (DMDP) is clinically employed for the treatment of osteolytic bone diseases. When encapsulated in … WebNov 1, 1984 · Outre leur action remarquable dans la maladie osseuse de Paget, les diphosphonates sont très efficaces dans le traitement des hypercalcémies dont l'origine osseuse est presque toujours essentielle. Dans les hypercalcémies malignes, l'EHDP, le CL2 MDP et l'APD, les trois diphosphonates testés chez l'homme font chuter la calcémie …

WebSep 1, 1996 · Abstract. Dichloromethylene diphosphonate (MDPCl 2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately …

WebJan 15, 2003 · Liposomally encapsulated clodronate (dichloromethylene diphosphonate) has previously been found to be a potent antimacrophage agent. It … dating websites for sugar daddiesWebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone macrophages in the mouse spleen which finally results in the elimination of these cells. bj\u0027s wholesale club holdings stockWebDichloromethylene diphosphonate can be used for temporary elimination of macrophages in the spleen when administered after entrapment in liposomes. No comp Elimination of … bj\u0027s wholesale club henrietta nyWebUveitis is characterized by inflammatory lesions of intraocular structures. It is one of the important manifestations in patients with Reiter’s syndrome, an inflammatory arthritis, which is caused by enteric infection with bacteria, including Salmonella typhimurium. Corticosteroids remain the most frequently used therapies against uveitis associating … bj\u0027s wholesale club home improvementWebIn mice administered with liposome-entrapped dichloromethylene diphosphonate, which depletes Kupffer cells, the size and the number of zymosan-induced granulomas in the liver were smaller than in untreated mice. The number of macrophage precursors, as detected by the monoclonal antibodies for macrophage precursors, increased after zymosan ... bj\u0027s wholesale club hialeah tiresWebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone … dating websites for professionals over 50WebSystemic treatment with disodium ethane-hydroxy-1, 1-diphosphonate is ineffective in inhibiting the calcergenic reactions induced in mouse skin by the lanthanides. In contrast, disodium dichloromethylene diphosphonate prevents lanthanide calcergy induced by 12 of the 15 compounds tested but only when treatment with Cl 2 MDP is given prior to ... dating websites for prisoners