Immunotoxicity testing in non-rodent species
WitrynaPresentation Title: Immunotoxicity Testing In Non-Rodent Species Presentation Description: Evaluation of the immunotoxicity potential of some pharmaceuticals, … WitrynaEPA Health Effects Test Guidelines OPPTS 870.3150, 90-Day Oral Toxicity in Non-Rodents, August 1998 OECD Guideline For The Testing Of Chemicals , Repeated …
Immunotoxicity testing in non-rodent species
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Witryna5 lis 2008 · 2. Maternal toxicity. Most of the reports of T-2 toxin-exposure to pregnant mice and rats are focused on embryo/fetal toxicity, with little reference to maternal toxicity [ 13, 30 – 40 ]. Sehata et al. [ 41, 42] examined the maternal toxicity in detail in pregnant rats exposed to a single oral dose of T-2 toxin (2 mg/kg) on day 13 of … WitrynaAnimals (Rodent and Non-rodent Toxicity Testing) •Studies: – Include at least two species ($1 non-rodent species) – Use inhalation (IH) route of administration or IH …
Witryna17 wrz 2007 · The most common assay used to assess immunotoxicity in rodents is the antibody response to sheep red blood cells (SRBCs) because it was found to be the most predictive single assay for immunotoxicity ( Luster et al., 1992) and requires cooperation between B, T, and antigen-presenting cells. This exact response cannot … WitrynaS4 Duration of Chronic Toxicity Testing in Animals (Rodent and Non Rodent Toxicity Testing) ... species selection, study design, immunogenicity, reproductive and …
Witryna9 paź 2008 · In these cases, the non-rodent species may be a more relevant model and thus methodologies that assess various components of the immune system have also been applied in studies with non-human primates and, more recently, dogs. This …
WitrynaNon-clinical investigation of the dependence potential of medicinal products - Scientific guideline. Background to the CPMP Position Paper on possible pre-clinical studies to …
Witryna1 maj 2003 · The immunotoxicity testing protocols described in the present chapter have been adapted for application to NHP samples. ... we summarize the process of selecting a relevant non-rodent species for ... philip morris antwerpenWitrynaTG 409, Repeated Dose 90-day Oral Toxicity Study in Non-Rodents (5). Additional information on choice of species and strain is provided in Guidance Document No. … philip morris anzolaWitryna22 lis 2016 · Prof. Dr. rer. nat. Armin Braun, is Division Director of the Preclinical Pharmacology and In Vitro Toxicology of the Fraunhofer Institute for Toxicology and … truham grammar school uniformWitrynaThe repeated-dose toxicity studies in animals are designed to include a similar or longer exposure time than the intended clinical trial duration in humans (see table below).As … philip morris apsWitryna23 mar 2024 · Products used in the pharmaceutical, farming, chemical, or consumer product industries. Immunotoxicity tests designed to evaluate immune function and … philip morris annual report 2022WitrynaThe use of non-rodent species may be considered when available data suggest that they are more relevant for the prediction of health effects in humans. ... If such studies … philip morris aps cvrWitryna22 sty 2016 · Adaptations of immunotoxicity assays have been described using non-rodent species. The species, strain, dose, duration, and route of administration used … philip morris annual revenue