Scd1 human
WebNov 16, 2024 · It turns long chain saturated fats into long chain monounsaturated fats. Insulin is an up-regulator of SCD1 and leptin down-regulates it. Insulin pushes your body fat towards unsaturation which causes you to store fat. Leptin pushes your body fat towards saturation which causes you to burn fat. Webstearoyl-CoA desaturase 1 inhibition induces CHOP-dependent cell death in human cancer cells. Oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of …
Scd1 human
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WebAug 24, 2024 · Two SCD isoforms have been identified in human tissues: SCD1 and SCD5 [52–54]. SCD1 is the main isoform, ubiquitously expressed, with a prevalence in adipose tissue, heart, brain, liver and lungs. SCD5 is poorly expressed in adult human tissues and is mostly restricted to the brain and pancreas. WebJun 22, 2015 · The residues on SCD1 that form contacts with the stearoyl-CoA are also conserved in other isoforms in humans (hSCD5) and in the mouse SCD (Supplementary Fig. 1).
WebImmunohistochemical analysis of paraffin-embedded human adipose tissue within cardiac muscle tissue labeling SCD1 with ab236868 at 1/2000 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) ready to use. Positive staining in human adipose cells in cardiac muscle (PMID: 15907797) is observed. Counter stained with hematoxylin. WebAll lanes : Anti-SCD1 antibody [EPR21963] at 1/1000 dilution Lane 1 : Wild-type HeLa cell lysate Lane 2 : SCD knockout HeLa cell lysate Lane 3 : HepG2 cell lysate Lysates/proteins …
WebCitations (64) Confocal immunofluorescent analysis of 3T3-L1 cells, using SCD1 (M38) Antibody (red) showing cytoplasmic localization in differentiated cells. Lipid droplets have been labeled with BODIPY … WebMar 29, 2024 · Organism. Lineage. Also known as. SCD1; FADS5; SCDOS; hSCD1; MSTP008. Summary. This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the …
WebAug 24, 2024 · SCD1 plays an important role in cancer, promoting cell proliferation and metastasis. The role of autophagy in cancer is more complex since it can act either by …
WebApr 18, 2024 · Cells with overexpressed SCD1 were resistant to Gefitinib. a, b The expression of SCD1 in five lung cancer cell lines A549, H838, H1573 and one normal human bronchial epithelial cells BEAS-2B was analyzed.c, d The cell vitality of A549 and H1573 with or without SCD1 overexpression was assessed after treatment with different doses of Gefitinib (0, 5, … how to check tyre treadWebFour SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 … how to check tyres for wearWebValidated for WB, IP, IHC, IF. Highly specific and rigorously validated in-house, SCD1 (C12H5) Rabbit Monoclonal Antibody (CST #2794) ... Human, Mouse. Source / Purification. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu35 of mouse SCD1. how to check tyre treadsWebAug 12, 2002 · In contrast to human subjects and several mouse models of lipodystrophy , the loss of adiposity in the SCD1−/− mice led to increased rather than decreased insulin sensitivity. In lipodystrophy, there is a redistribution in the lipogenic burden away from adipose tissue, leading to triglyceride accumulation in the liver and in skeletal muscle. how to check tyres are legalWebHere we report the 3.25-Å crystal structure of human SCD1 in complex with its substrate, stearoyl-coenzyme A, which defines the new SCD1 dimetal catalytic center and reveals … how to check tyre tread with 20pWebJun 6, 2002 · Function. Stearoyl-CoA desaturase that utilizes O 2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates … how to check tyre wear ukWebSCD1 is known to undergo post-translational modifications and the sizes differ in different cell lines so the observed band size can be different than predicted band size. As positive control we recommend using SCD1 over-expressed 293 transfected cell lysates for western blot. This product was changed from ascites to tissue culture supernatant ... how to check uan status online uk