The pleiotropic benefits of statins

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August undefined, 2024

Webb31 dec. 2024 · Other Advantages of Statins. One of the most interesting truths about statin drugs is actually not related to cholesterol at all. Statins are anti-inflammatories. This is called a pleiotropic effect, i.e. a beneficial effect outside of what was expected. WebbInhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be involved, at least partially, in the improvement of endothelial function, modulation of immune function, and other pleiotropic cardiovascular benefits of statins, as well as in the fact that a number of other drugs that lower LDL …

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Webb1 maj 2024 · The so-called pleiotropic effects are mediated by the reduction of isoprenoids, such as farnesyl-pyrophosphate and geranylgeranyl-pyrophosphate, necessary for the activation of small GTPases like Rho and Ras proteins (Fig. 1A).Statins diversely inhibit RhoA and Rac1 prenylation, modulating endothelial nitric oxide (NO) synthase … Webb6 jan. 2024 · The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol … small standing computer desk with wheels

Effects of statin therapy on renal outcomes CLEP

Webb1 feb. 2015 · The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. The concept of lipoproteins as lipid transporters has evolved to encompass functions in coagulation, inflammation, and redox reactions due to their unique protein cargo. WebbCurrently, new benefits of statins, not dependent on the reduction of LDL cholesterol, have been proposed in the setting of ACS. These effects, which are not dependent on the reduction of LDL cholesterol, are called pleiotropic [Liao, 2005]. Some of the possible effects of statins, which may participate in the benefits that they represent for Webb12 juni 2015 · This finding “suggests that reduction of LDL cholesterol levels per se explains the effect of statins on coronary heart disease,” rather than some pleiotropic benefit specific to statins, the editorialists wrote. “It’s nice to have all the different options for patients,” Cannon said. small standing height table

Pleiotropic effects of statins Tandon V, Bano G, Khajuria V, Parihar …

WebbAccumulating evidence have suggested that statins, in addition to LDL-C lowering, exhibited properties of plaque stabilization and endothelial homeostasis; anti … Webb8 apr. 2024 · The greatest improvements were recorded in the fluvastatin and dual therapy groups, suggesting the statin had played a dominant role. 28 Remarkably, a significant increase in nitric oxide and reduction in endothelin-1 was observed in the two groups receiving statins, indicating that the pleiotropic effects of this drug are fundamental for … small standing jewelry boxWebbStatins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated ... highway amazon movie

"Webb3 okt. 2024 · ObjectiveTo conduct risk assessment and assess the choice of statins ... with no difference between urban and rural areas. 6 Given the burden of CVD and lipid-lowering benefits of statins, ... cholesterol is present in 25% to 30% of urban and 15% to 20% rural subjects. 7 Statins have lipid lowering and number of pleiotropic ... " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Basic Science Review: Statin Therapy-Part I: The Pleiotropic …

WebbAs a result of their pleiotropic effects statins modulate virtually all known processes of atherosclerosis and have beneficial effects outside the cardiovascular system Statins … WebbThis paper builds on these findings and presents practical guidance for maximising the pleiotropic benefits of this class of medicines in people with T2DM in terms of reducing adverse CVD outcomes. The Improving Diabetes Steering Committee aims to offer evidence-based practical guidance for the use of SGLT2i therapies in people with T2DM …

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WebbThe noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque … WebbBeneficial Cardiovascular Pleiotropic Effects of Statins Jean Davignon, MD Abstract—Pleiotropic effects of a drug are actions other than those for which the agent …

Webb5 jan. 2012 · Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory … WebbThe cardiovascular risk benefits as well as the potential pleiotropic benefits of statins warrants strong consideration of use of statin therapy in patients with cirrhosis. Although 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (‘statins’) reduce the risk of cardiovascular events, fears about hepatotoxicity have historically led to underuse in …

WebbConcerns about the hazards of statins on the development and mortality of stomach cancers remain controversial. Here, we investigated the likelihood of incident gastric cancers and related mortality depending on statin exposure, statin type, and the duration of use. This nested case–control-designed study was composed of 8798 patients who … WebbOur study suggests that prior statin use, especially long-term lipophilic statin use, appears to confer preventive benefits against RA. Safety issues regarding the potential risk of …

Webb25 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis. Nat. Cardiovasc. Res. 1, …

Webbwith cardiac history. How might the increasing use of statins, with pleiotropic effects, including antiinflammatory activity, alter the effects of immunization? With universal recommendations for influenza vaccination for persons > 6 months of age, how will herd or community immunity affect population levels of influenza activity? small standing desk with storageWebb13 feb. 2024 · Indeed, several randomized controlled trials showed the benefits of statins both in the primary and secondary prevention of cardiovascular disease, which appear to be primarily due to LDL cholesterol (LDL-C) reduction but also to antiinflammatory, antithrombotic, antioxidant, and plaque-stabilizing effects [5,6,7,8,9,10,11,12]. small standing for water in dishwasherWebb15 juni 2007 · Furthermore, at normal doses, statins inhibit cholesterol metabolism by macrophages and may lead to a reduction in macrophage activation and participation in atherogenesis. 18 In vitro immune modulating activities have also been demonstrated by some statins, including regulation of natural killer cell activity, and may be the basis of … highway amoco evansville mnWebb6 jan. 2024 · Pleiotropic Effects of Statins on the Cardiovascular System. The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary … highway americaWebb30 apr. 2024 · This misconception, and therefore reluctance to prescribe statins, may indirectly deny patients with chronic liver disease significant clinical benefit (Fig. 1).Unrelated to its lipid-lowering effects, statins have a wide array of pleiotropic effects, ranging from antioxidant, antifibrotic, anti-inflammatory, and improvement of endothelial … highway and bridge engineeringWebbDespite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, … highway anand devarakondaWebbPleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, … small standing shelf for kitchen